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ChEMBL ligand: CHEMBL4210652 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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glutathione S-transferase omega 1/Glutathione transferase omega 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3174] [GtoPdb: 3110] [UniProtKB: P78417] | ||||||||
ChEMBL | Inhibition of recombinant GSTO1-1 (unknown origin) expressed in Escherichia coli assessed as inhibitor constant using S-(4-nitrophenacyl)glutathione as substrate preincubated for 1 to 6 mins followed by substrate addition by spectrophotmetric analysis | B | 6.36 | pKi | 440 | nM | Ki | J Med Chem (2020) 63: 2894-2914 [PMID:32105470] |
ChEMBL | Inhibition of recombinant GSTO1-1 (unknown origin) expressed in Escherichia coli using S-(4-nitrophenacyl)glutathione as substrate preincubated for 2 mins followed by substrate addition by 4-NPG assay | B | 6.89 | pIC50 | 130 | nM | IC50 | J Med Chem (2020) 63: 2894-2914 [PMID:32105470] |
GtoPdb | - | - | 6.89 | pIC50 | 130 | nM | IC50 | J Med Chem (2020) 63: 2894-2914 [PMID:32105470] |
ChEMBL | Inhibition of GSTO1-1 (unknown origin) by enzymatic assay | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (2018) 61: 7448-7470 [PMID:29652143] |
ChEMBL | Inhibition of CMFDA binding to human N-terminal 6x-His-tagged GSTO1-1 preincubated for 30 mins followed by CMFDA addition and measured after 30 mins by in-gel fluorescence binding assay | B | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (2019) 62: 3068-3087 [PMID:30735370] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]