ceftobiprole [Ligand Id: 10787] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL520642 (BAL-9141-000, BAL-9141000, BAL9141-000, Ceftobiprole, RO 63-9141, RO-63-9141, RO-639141, Zeftera, Zevtera)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MecA in S.aureus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6187] [UniProtKB: Q7DHH4]
ChEMBL Binding affinity to Staphylococcus aureus ATCC 433000 PBP2a by Western blotting at pH 5.5 in presence of 100 uM Bocillin FL B 5.13 pIC50 7400 nM IC50 Antimicrob Agents Chemother (2009) 53: 2289-2297 [PMID:19289525]
ChEMBL Inhibition of methicillin-resistant Staphylococcus aureus COL PBP2a by competitive assay B 5.49 pIC50 3200 nM IC50 Antimicrob Agents Chemother (2008) 52: 2709-2717 [PMID:18505853]
ChEMBL Binding affinity to Staphylococcus aureus ATCC 433000 PBP2a by Western blotting at pH 7.4 in presence of 100 uM Bocillin FL B 5.72 pIC50 1900 nM IC50 Antimicrob Agents Chemother (2009) 53: 2289-2297 [PMID:19289525]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]