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ChEMBL ligand: CHEMBL443 (Acetylsulfamethoxazole, Gantanol, Gantanol-ds, NSC-147832, RO 4-2130, RO-4-2130, Sinomin, STX-608, Sulfamethoxazole, Sulfamethoxazole sodium, Sulfamethoxazolum, Sulphamethoxazole, Suphamethoxazole, Urobak) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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6-phospho-1-fructokinase in Trypanosoma brucei (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5686] [UniProtKB: O15648] | ||||||||
ChEMBL | Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay | B | 4.24 | pIC50 | >57000 | nM | IC50 | ACS Med Chem Lett (2014) 5: 12-17 [PMID:24900769] |
Dihydrofolate reductase in Pneumocystis carinii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1926] [UniProtKB: P16184] | ||||||||
ChEMBL | Inhibitory activity against dihydrofolate reductase in Pneumocystis carinii in the prence of 100 micro M PABA. | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (1995) 38: 4739-4759 [PMID:7490723] |
Dihydropteroate synthase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4032] [UniProtKB: P0AC13] | ||||||||
ChEMBL | In vitro inhibition of dihydropteroate synthase from Escherichia coli. | B | 5.33 | pIC50 | 4700 | nM | IC50 | J Med Chem (1985) 28: 1870-1874 [PMID:3906132] |
ETA receptor/Endothelin receptor ET-A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4566] [GtoPdb: 219] [UniProtKB: P26684] | ||||||||
ChEMBL | Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells. | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (1995) 38: 1344-1354 [PMID:7731020] |
ChEMBL | Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (1995) 38: 659-668 [PMID:7861414] |
Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL243] [UniProtKB: Q72874] | ||||||||
ChEMBL | Binding affinity for human immunodeficiency virus type 1 protease | B | 6.24 | pKd | 577 | nM | Kd | J Med Chem (2004) 47: 5953-5961 [PMID:15537350] |
ChEMBL | Inhibition constant for human immunodeficiency virus type 1 protease | B | 8 | pKi | 10.1 | nM | Ki | J Med Chem (2004) 47: 5953-5961 [PMID:15537350] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]