Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL483 (Atripla, GS-1275, PMP-A, Tenofovir, Truvada) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Core antigen in Hepatitis B virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075091] [UniProtKB: Q03732] | ||||||||
ChEMBL | Inhibition of hepatitis B virus capsid assembly infected in human HepG2.215 cells assessed as reduction in viral DNA replication measured on day 7 by real time PCR analysis | B | 6.62 | pEC50 | 241.5 | nM | EC50 | Bioorg Med Chem (2017) 25: 1042-1056 [PMID:28082068] |
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547] | ||||||||
ChEMBL | Binding affinity to ternary complex of HIV1 reverse transcriptase with primer/template in presence of dCTP substrate | B | 5.49 | pKd | 3200 | nM | Kd | Antimicrob Agents Chemother (2007) 51: 2911-2919 [PMID:17517852] |
ChEMBL | Inhibition of HIV1 reverse transcriptase | B | 6.42 | pIC50 | 380 | nM | IC50 | Bioorg Med Chem (2007) 15: 5519-5528 [PMID:17562366] |
ChEMBL | Inhibition of wild type HIV 3B reverse transcriptase in MT2 cells | B | 6.42 | pIC50 | 380 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1120-1123 [PMID:18164198] |
ChEMBL | Inhibition on HIV1 reverse transcriptase p66/p51 | B | 6.42 | pIC50 | 380 | nM | IC50 | Bioorg Med Chem (2009) 17: 1739-1746 [PMID:19179082] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]