DPO-1 [Ligand Id: 11207] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1088844 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv1.5/Voltage-gated potassium channel subunit Kv1.5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4306] [GtoPdb: 542] [UniProtKB: P22460] | ||||||||
| ChEMBL | Inhibition of human Kv1.5 ion channel after 3 mins by high-throughput planar patch clamp assay | B | 6.3 | pIC50 | 500 | nM | IC50 | ACS Med Chem Lett (2012) 3: 769-773 [PMID:24900546] |
| GtoPdb | Inhibition of human Kv1.5 channel expressed in CHO cells by whole cell patch clamp assay. | - | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2493-6 [PMID:20304642] |
| ChEMBL | Inhibition of human Kv1.5 channel expressed in CHO cells by whole cell patch clamp assay | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2493-2496 [PMID:20304642] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
