dasabuvir [Ligand Id: 11270] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3137312 (ABT-333, Dasabuvir, Dasabuvir sodium monohydrate, Exviera) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Hepatitis C virus NS5B RNA-dependent RNA polymerase in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5375] [UniProtKB: Q8JXU8] | ||||||||
| ChEMBL | Inhibition of HCV genotype 1b NS5B RNA dependent RNA polymerase | B | 8.74 | pEC50 | 1.8 | nM | EC50 | Medchemcomm (2019) 10: 991-1006 [PMID:31303998] |
| cereblon/Protein cereblon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3763008] [GtoPdb: 3086] [UniProtKB: Q96SW2] | ||||||||
| ChEMBL | Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MST based assay | B | 5.33 | pKi | 4710 | nM | Ki | ACS Med Chem Lett (2021) 12: 74-81 [PMID:33488967] |
| ChEMBL | Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MST based assay | B | 4.81 | pIC50 | 15600 | nM | IC50 | ACS Med Chem Lett (2021) 12: 74-81 [PMID:33488967] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
