opiorphin [Ligand Id: 11538] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2022225 (Opiorphin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Aminopeptidase N in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1907] [GtoPdb: 1560] [UniProtKB: P15144] | ||||||||
| ChEMBL | Inhibition of human recombinant AP-N ectopeptidase activity using alanine-MCA as substrate preincubated for 10 mins with substrate by fluorimetric analysis | B | 5.09 | pIC50 | 8100 | nM | IC50 | J Med Chem (2012) 55: 1181-1188 [PMID:22224710] |
| ChEMBL | Inhibition of human recombinant aminopeptidase N using AbzdR-G-L-EDDnp as substrate after 20 to 40 mins by fluorometry | B | 5.09 | pIC50 | 8100 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 5190-5193 [PMID:26463133] |
| ChEMBL | Inhibition of human recombinant aminopeptidase N using Ala-Mca as substrate incubated for 10 mins prior to substrate addition measured for 40 mins by fluorometry | B | 5.1 | pIC50 | 8000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 20-24 [PMID:24900367] |
| GtoPdb | - | - | 5.1 | pIC50 | 8000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 20-4 [PMID:24900367] |
| Neutral endopeptidase/Neprilysin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944] [GtoPdb: 1611] [UniProtKB: P08473] | ||||||||
| ChEMBL | Inhibition of human recombinant NEP ectopeptidase activity using Abz-dRGL-(EDDnp) as substrate preincubated for 10 mins with substrate by fluorimetric analysis | B | 4.52 | pIC50 | 30000 | nM | IC50 | J Med Chem (2012) 55: 1181-1188 [PMID:22224710] |
| ChEMBL | Inhibition of human recombinant neprilysin using Abz-dR-G-L-EDDnp as substrate incubated for 10 mins prior to substrate addition measured for 40 mins by fluorometry | B | 4.52 | pIC50 | 30000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 20-24 [PMID:24900367] |
| ChEMBL | Inhibition of human recombinant neutral endopeptidase using Ala-AMC as substrate after 20 to 40 mins by fluorometry | B | 4.52 | pIC50 | 30000 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 5190-5193 [PMID:26463133] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
