SBC-115,337 [Ligand Id: 11539] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4458097 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| proprotein convertase subtilisin/kexin type 9/Subtilisin/kexin type 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2929] [GtoPdb: 2388] [UniProtKB: Q8NBP7] | ||||||||
| GtoPdb | Inhibition of the PCSK9/ LDLR interaction in an ELISA | - | 6.3 | pIC50 | 500 | nM | IC50 | WO2017222953A1. Anti-proprotein convertase subtilisin kexin type 9 (anti-pcsk9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases (2017) |
| ChEMBL | Inhibition of His-tagged PCSK9 (unknown origin) binding to recombinant LDLR-AB domain (unknown origin) by ELISA | B | 6.3 | pIC50 | 500 | nM | IC50 | Eur J Med Chem (2019) 162: 212-233 [PMID:30448414] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
