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ChEMBL ligand: CHEMBL295698 ((-)-(2s,4r)-ketoconazole, 2s,4r ketoconazole, 2s,4r-ketoconazole, COR-003, COR003, DIO-902, Extina, Ketoconazole, (2s,4r)-, Ketosidin, Ketozole, Levoketoconazole, Nizoral, Nizoral A-D, Normocort, Panfungol, R-41400, Recorlev, Xolegel) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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CYP11B1 in Bovine [GtoPdb: 1359] | ||||||||
GtoPdb | - | - | 6.22 | pIC50 | 608 | nM | IC50 | J Med Chem (1992) 35: 2818-25 [PMID:1495014] |
CYP17A1 in Human [GtoPdb: 1361] [UniProtKB: P05093] | ||||||||
GtoPdb | - | - | 7.42 | pKi | 38 | nM | Ki | J Med Chem (1998) 41: 902-12 [PMID:9526564] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]