batoprotafib [Ligand Id: 12068] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL4650521 (Batoprotafib, Ptpn11 inhibitor tno155, Shp2 inhibitor tno155, Tno 155, Tno-155, Tno155, TNO-155, TNO155)
There should be some charts here, you may need to enable JavaScript!
  • protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG by Q-patch assay B 4.52 pIC50 >30000 nM IC50 J Med Chem (2020) 63: 13578-13594 [PMID:32910655]
protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124]
ChEMBL Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY122 incubated for 30 mins by fluorescence based DIFMUP assay B 7.96 pIC50 11 nM IC50 J Med Chem (2020) 63: 13578-13594 [PMID:32910655]
ChEMBL Allosteric inhibition of human SHP2 in human KYSE-520 cells assessed as reduction in ERK1/2 phosphorylation by fluorescence based assay B 7.96 pIC50 11 nM IC50 J Med Chem (2020) 63: 13578-13594 [PMID:32910655]
GtoPdb - - 7.96 pIC50 11 nM IC50 J Med Chem (2020) 63: 13578-13594 [PMID:32910655]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]