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ChEMBL ligand: CHEMBL208943 (CP-640186) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Acetyl-CoA carboxylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3351] [GtoPdb: 1263] [UniProtKB: Q13085] | ||||||||
ChEMBL | Inhibition of N-terminal His-tagged human recombinant ACC1 expressed in high five insect cells by ATP consumption assay | B | 6.04 | pIC50 | 910 | nM | IC50 | J Med Chem (2010) 53: 8679-8687 [PMID:21082864] |
ChEMBL | Inhibition of human ACC1 | B | 6.26 | pIC50 | 550 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 6314-6318 [PMID:21944854] |
ChEMBL | Inhibition of human recombinant ACC1 | B | 6.34 | pIC50 | 456 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6645-6648 [PMID:19853443] |
ChEMBL | Inhibition of human recombinant ACC1 expressed in HEK293 cells | B | 6.39 | pIC50 | 410 | nM | IC50 | J Med Chem (2006) 49: 3770-3773 [PMID:16789734] |
ChEMBL | Inhibition of human recombinant ACC1 | B | 6.39 | pIC50 | 410 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 6078-6081 [PMID:16973360] |
GtoPdb | - | - | 6.39 | pIC50 | 410 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 6078-81 [PMID:16973360] |
Acetyl-CoA carboxylase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2397] [GtoPdb: 1263] [UniProtKB: P11497] | ||||||||
ChEMBL | Inhibition of N-terminal His-tagged rat recombinant ACC1 expressed in high five insect cells by ATP consumption assay | B | 6.23 | pIC50 | 590 | nM | IC50 | J Med Chem (2010) 53: 8679-8687 [PMID:21082864] |
ChEMBL | Inhibition of obese Zucker rat ACC1 assessed as reduction in hepatic malonyl-coA level preincubated for 15 mins measured after 1.5 hrs using Malachite green reagent method | B | 6.64 | pIC50 | 230 | nM | IC50 | Bioorg Med Chem (2011) 19: 3039-3053 [PMID:21515056] |
ChEMBL | Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter | B | 7.04 | pIC50 | 92 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2383-2388 [PMID:20219367] |
ChEMBL | Inhibition of rat acetyl-CoA carboxylase 1 | B | 7.26 | pIC50 | 55 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 949-953 [PMID:19097787] |
ChEMBL | Inhibitory activity against rat ACC1 | B | 7.28 | pIC50 | 53 | nM | IC50 | J Med Chem (2006) 49: 3770-3773 [PMID:16789734] |
ChEMBL | Inhibition of rat ACC1 | B | 7.28 | pIC50 | 53 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6645-6648 [PMID:19853443] |
GtoPdb | - | - | 7.28 | pIC50 | 53 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6645-8 [PMID:19853443] |
Acetyl-CoA carboxylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4829] [GtoPdb: 1264] [UniProtKB: O00763] | ||||||||
ChEMBL | Inhibition of human recombinant ACC2 | B | 6.71 | pIC50 | 194 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6645-6648 [PMID:19853443] |
ChEMBL | Inhibition of N-terminal His-tagged human recombinant ACC2 expressed in high five insect cells by ATP consumption assay | B | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (2010) 53: 8679-8687 [PMID:21082864] |
ChEMBL | Inhibitory activity against rat ACC2 | B | 7.21 | pIC50 | 61 | nM | IC50 | J Med Chem (2006) 49: 3770-3773 [PMID:16789734] |
GtoPdb | - | - | 7.42 | pIC50 | 38 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 6078-81 [PMID:16973360] |
ChEMBL | Inhibition of human recombinant ACC2 expressed in baculovirus/sf9 system | B | 7.42 | pIC50 | 38 | nM | IC50 | J Med Chem (2006) 49: 3770-3773 [PMID:16789734] |
ChEMBL | Inhibition of human recombinant ACC2 | B | 7.42 | pIC50 | 38 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 6078-6081 [PMID:16973360] |
ChEMBL | Inhibition of human ACC2 | B | 7.47 | pIC50 | 34 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 6314-6318 [PMID:21944854] |
Acetyl-CoA carboxylase 2 in Rat [GtoPdb: 1264] | ||||||||
GtoPdb | - | - | 7.21 | pIC50 | 61 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6645-8 [PMID:19853443] |
Acetyl-Coenzyme A carboxylase 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5125] [UniProtKB: Q1HEC0] | ||||||||
ChEMBL | Inhibition of ACC2 in obese Zucker rat assessed as reduction in hepatic malonyl-coA level preincubated for 15 mins measured after 1.5 hrs using Malachite green reagent method | B | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem (2011) 19: 3039-3053 [PMID:21515056] |
ChEMBL | Inhibition of rat ACC2 | B | 7.21 | pIC50 | 61 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6645-6648 [PMID:19853443] |
ChEMBL | Inhibition of rat acetyl-CoA carboxylase 2 | B | 7.26 | pIC50 | 55 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 949-953 [PMID:19097787] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]