aristolochic acid [Ligand Id: 12438] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL93353 (Aristolochic Acid I) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
| ChEMBL | Inhibition of CDK2 | B | 4.7 | pIC50 | >20000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1384-1387 [PMID:20097066] |
| TAS2R14 in Human [GtoPdb: 668] [UniProtKB: Q9NYV8] | ||||||||
| GtoPdb | - | - | 6.31 | pEC50 | 490 | nM | EC50 | Biochim Biophys Acta Gen Subj (2018) 1862: 2162-2173 [PMID:30009876] |
| TAS2R31 in Human [GtoPdb: 674] [UniProtKB: P59538] | ||||||||
| GtoPdb | - | - | 6.35 | pEC50 | 450 | nM | EC50 | J Neurosci (2004) 24: 10260-5 [PMID:15537898] |
| TAS2R43 in Human [GtoPdb: 678] [UniProtKB: P59537] | ||||||||
| GtoPdb | - | - | 7.1 | pEC50 | 80 | nM | EC50 | J Neurosci (2004) 24: 10260-5 [PMID:15537898] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
