ChEMBL ligand: CHEMBL284616 (5-cqa, Chlorogenic acid, Cp chlorogenic acid, Heriguard, NSC-407296, NSC-70861, Trans-5-o-caffeoylquinic acid, Trans-caffeic acid 5-o-d-quinate, Trans-chlorogenic acid)
Aldo-keto reductase family 1 member B10 in Human [ChEMBL: CHEMBL5983] [UniProtKB: O60218] There should be some charts here, you may need to enable JavaScript!
aldo-keto reductase family 1 member B/Aldose reductase in Human [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] aldo-keto reductase family 1 member B/Aldose reductase in Rat [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] There should be some charts here, you may need to enable JavaScript!
Beta-1,3-glucan synthase in Candida albicans [ChEMBL: CHEMBL2037] [UniProtKB: O13383] There should be some charts here, you may need to enable JavaScript!
Beta amyloid A4 protein in Human [ChEMBL: CHEMBL2487] [UniProtKB: P05067] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1] There should be some charts here, you may need to enable JavaScript!
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] There should be some charts here, you may need to enable JavaScript!
protein tyrosine phosphatase non-receptor type 2/T-cell protein-tyrosine phosphatase in Human [ChEMBL: CHEMBL3807] [GtoPdb: 3255] [UniProtKB: P17706] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218]
ChEMBL	Inhibition of human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by spectrometric analysis	B	5.1	pIC50	7900	nM	IC50	Eur J Med Chem (2012) 48: 321-329 [PMID:22236472]
aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
ChEMBL	Inhibition of human recombinant aldose reductase using D-glyceraldehyde as substrate preincubated for 10 mins before substrate addition measured for every 10 secs for 50 mins by spectrophotometry	B	5.74	pIC50	1800	nM	IC50	Bioorg Med Chem (2012) 20: 1251-1258 [PMID:22261024]
ChEMBL	Inhibition of human recombinant N-terminus His6-tagged AKR1B1 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by spectrometric analysis	B	6.52	pIC50	300	nM	IC50	Eur J Med Chem (2012) 48: 321-329 [PMID:22236472]
aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943]
ChEMBL	Inhibition of Sprague-Dawley rat lens aldose reductase	B	6.02	pIC50	950	nM	IC50	J Nat Prod (2012) 75: 267-270 [PMID:22264115]
Beta-1,3-glucan synthase in Candida albicans (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2037] [UniProtKB: O13383]
ChEMBL	Inhibition of Candida albicans 1,3 beta-D-glucan synthase	B	4.05	pIC50	>90000	nM	IC50	Bioorg Med Chem (2010) 18: 7009-7014 [PMID:20813534]
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL	Inhibition of human amyloid beta (1 to 42) aggregation after 24 hrs by thioflavin-T fluorescence assay	B	4.03	pIC50	92900	nM	IC50	Bioorg Med Chem (2012) 20: 5844-5849 [PMID:22921742]
Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1]
ChEMBL	Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing	B	4.06	pIC50	87800	nM	IC50	J Med Chem (2000) 43: 2100-2114 [PMID:10841789]
ChEMBL	Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 1	B	4.06	pIC50	87800	nM	IC50	J Med Chem (1997) 40: 942-951 [PMID:9083483]
ChEMBL	Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 2	B	4.24	pIC50	58200	nM	IC50	J Med Chem (1997) 40: 942-951 [PMID:9083483]
ChEMBL	Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer	B	4.34	pIC50	45800	nM	IC50	J Med Chem (2000) 43: 2100-2114 [PMID:10841789]
ChEMBL	Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 1	B	4.34	pIC50	45800	nM	IC50	J Med Chem (1997) 40: 942-951 [PMID:9083483]
ChEMBL	Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 2	B	4.5	pIC50	31300	nM	IC50	J Med Chem (1997) 40: 942-951 [PMID:9083483]
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL	Non-competitive inhibition of PTP1B (unknown origin) using p-NPP as substrate by Lineweaver-Burk plot analysis	B	4.82	pKi	15100	nM	Ki	Bioorg Med Chem Lett (2018) 28: 1194-1197 [PMID:29525218]
ChEMBL	Inhibition of PTP1B (unknown origin)	B	4.95	pIC50	11100	nM	IC50	Bioorg Med Chem Lett (2018) 28: 1194-1197 [PMID:29525218]
GtoPdb	-	-	4.96	pIC50	11000	nM	IC50	Bioorg Med Chem (2021) 44: 116295 [PMID:34246920]
ChEMBL	Inhibition of PTP1B (unknown origin)	B	7	pIC50	100	nM	IC50	Bioorg Med Chem (2021) 44: 116295-116295 [PMID:34246920]
protein tyrosine phosphatase non-receptor type 2/T-cell protein-tyrosine phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3807] [GtoPdb: 3255] [UniProtKB: P17706]
ChEMBL	Inhibition of TCPTP (unknown origin)	B	4.11	pIC50	77900	nM	IC50	Bioorg Med Chem Lett (2018) 28: 1194-1197 [PMID:29525218]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]