JMS-053 [Ligand Id: 12480] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4445621 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
| ChEMBL | Inhibition of human PTP1B assessed as reduction in hydrolysis using DIFMUP as substrate incubated for 30 mins in presence of DTT by Fluorescence based method | B | 4.1 | pIC50 | >80000 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 2008-2015 [PMID:31307888] |
| protein tyrosine phosphatase 4A3/Protein-tyrosine phosphatase 4A3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4162] [GtoPdb: 3224] [UniProtKB: O75365] | ||||||||
| ChEMBL | Inhibition of recombinant human PTP4A3 | B | 7.08 | pIC50 | 84 | nM | IC50 | Bioorg Med Chem Lett (2021) 46: 128167-128167 [PMID:34089839] |
| ChEMBL | Inhibition of recombinant human His-6-tagged PTP4A3 expressed in Escherichia coli assessed as reduction in hydrolysis using DIFMUP as substrate incubated for 30 mins in presence of DTT by Fluorescence based method | B | 7.46 | pIC50 | 35 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 2008-2015 [PMID:31307888] |
| ChEMBL | Inhibition of recombinant human His6-tagged PRL-3 expressed in Escherichia coli using DiFMUP as substrate incubated for 30 mins by fluorescence based assay | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2021) 41: 127981-127981 [PMID:33766767] |
| GtoPdb | Inhibition of recombinant human His6-tagged PRL-3, using DiFMUP as substrate in a fluorescence based assay. | - | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2021) 41: 127981 [PMID:33766767] |
| Protein tyrosine phosphatase type IVA 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075169] [UniProtKB: Q93096] | ||||||||
| ChEMBL | Inhibition of PTP4A1 (unknown origin) expressed in Escherichia coli assessed as reduction in hydrolysis using DIFMUP as substrate incubated for 30 mins in presence of DTT by Fluorescence based method | B | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 2008-2015 [PMID:31307888] |
| Protein tyrosine phosphatase type IVA 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075105] [UniProtKB: Q12974] | ||||||||
| ChEMBL | Inhibition of PTP4A2 (unknown origin) expressed in Escherichia coli assessed as reduction in hydrolysis using DIFMUP as substrate incubated for 30 mins in presence of DTT by Fluorescence based method | B | 7.28 | pIC50 | 52 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 2008-2015 [PMID:31307888] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
