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ChEMBL ligand: CHEMBL2180137 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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P2X1/P2X purinoceptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2094] [GtoPdb: 478] [UniProtKB: P51575] | ||||||||
ChEMBL | Antagonist activity at human P2X1 receptor by cell-based calcium influx assay | F | 5.19 | pIC50 | 6520 | nM | IC50 | J Med Chem (2012) 55: 9576-9588 [PMID:23075067] |
P2X2/P2X purinoceptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2531] [GtoPdb: 479] [UniProtKB: Q9UBL9] | ||||||||
ChEMBL | Antagonist activity at human P2X2 receptor by cell-based calcium influx assay | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 9576-9588 [PMID:23075067] |
P2X3/P2X purinoceptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2998] [GtoPdb: 480] [UniProtKB: P56373] | ||||||||
ChEMBL | Antagonist activity at human P2X3 receptor by cell-based calcium influx assay | F | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2012) 55: 9576-9588 [PMID:23075067] |
P2X4/P2X purinoceptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2104] [GtoPdb: 481] [UniProtKB: Q99571] | ||||||||
GtoPdb | - | - | 6.7 | pIC50 | 199 | nM | IC50 | J Med Chem (2012) 55: 9576-88 [PMID:23075067] |
ChEMBL | Antagonist activity at human P2X4 receptor expressed in 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx compound preincubated for 30 mins before ATP treatment by Fluo-4 AM fluorescence method | F | 6.72 | pIC50 | 189 | nM | IC50 | J Med Chem (2012) 55: 9576-9588 [PMID:23075067] |
ChEMBL | Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubated for 30 mins followed by ATP addition by Fluo-4 AM dye-based fluorescence assay | B | 6.72 | pIC50 | 189 | nM | IC50 | Bioorg Med Chem (2014) 22: 1077-1088 [PMID:24411477] |
P2X4/P2X purinoceptor 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176849] [GtoPdb: 481] [UniProtKB: Q9JJX6] | ||||||||
ChEMBL | Antagonist activity at mouse P2X4 receptor by cell-based calcium influx assay | F | 5.75 | pIC50 | 1770 | nM | IC50 | J Med Chem (2012) 55: 9576-9588 [PMID:23075067] |
P2X4/P2X purinoceptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2818] [GtoPdb: 481] [UniProtKB: P51577] | ||||||||
ChEMBL | Antagonist activity at rat P2X4 receptor by cell-based calcium influx assay | F | 5.68 | pIC50 | 2100 | nM | IC50 | J Med Chem (2012) 55: 9576-9588 [PMID:23075067] |
P2X7/P2X purinoceptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4805] [GtoPdb: 484] [UniProtKB: Q99572] | ||||||||
ChEMBL | Antagonist activity at human P2X7 receptor by cell-based calcium influx assay | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 9576-9588 [PMID:23075067] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]