lonidamine [Ligand Id: 12601] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1257030 (Doridamina, Lonidamine, NSC-741419, NSC-758419) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | DNDI: Malaria in Vitro, 72 hour | F | 4.81 | pIC50 | >15570 | nM | IC50 | Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning |
| mitochondrial pyruvate carrier 2 in Human [GtoPdb: 3023] [UniProtKB: O95563] | ||||||||
| GtoPdb | - | - | 5.34 | pIC50 | 4600 | nM | IC50 | Mol Metab (2022) 60: 101469 [PMID:35278701] |
| mitochondrial pyruvate carrier 2 in Rat [GtoPdb: 3023] [UniProtKB: P38718] | ||||||||
| GtoPdb | - | - | 5.6 | pIC50 | 2500 | nM | IC50 | Biochem J (2016) 473: 929-36 [PMID:26831515] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
