metatinib [Ligand Id: 12614] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2143592 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
| ChEMBL | Competitive inhibition of c-Met (unknown origin) in presence of ATP | B | 8.77 | pIC50 | 1.7 | nM | IC50 | Eur J Med Chem (2016) 108: 495-504 [PMID:26717201] |
| macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2689] [GtoPdb: 1816] [UniProtKB: Q04912] | ||||||||
| ChEMBL | Inhibition of Ron (unknown origin) | B | 8.52 | pIC50 | <3 | nM | IC50 | Eur J Med Chem (2016) 108: 495-504 [PMID:26717201] |
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Inhibition of Flt-3 (unknown origin) | B | 8.52 | pIC50 | <3 | nM | IC50 | Eur J Med Chem (2016) 108: 495-504 [PMID:26717201] |
| AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530] | ||||||||
| ChEMBL | Inhibition of Axl (unknown origin) | B | 8.52 | pIC50 | <3 | nM | IC50 | Eur J Med Chem (2016) 108: 495-504 [PMID:26717201] |
| kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| ChEMBL | Competitive inhibition of VEGFR2 (unknown origin) in presence of ATP | B | 7.82 | pIC50 | 15 | nM | IC50 | Eur J Med Chem (2016) 108: 495-504 [PMID:26717201] |
| MER proto-oncogene, tyrosine kinase in Human [GtoPdb: 1837] [UniProtKB: Q12866] | ||||||||
| GtoPdb | - | - | 7.65 | pKi | 22.4 | nM | Ki | Exp Mol Med (2022) 54: 1450-1460 [PMID:36056187] |
| GtoPdb | Inhibition at intracellular ATP concentration of 1 mM | - | 6.89 | pIC50 | 129.9 | nM | IC50 | Exp Mol Med (2022) 54: 1450-1460 [PMID:36056187] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
