example 31 [WO2018183145] [Ligand Id: 12666] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4442295
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GPR6/G-protein coupled receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3714130] [GtoPdb: 85] [UniProtKB: P46095]
GtoPdb Inhibition of GPR6 constitutive cAMP activity in CHO-K1 cells. - 7.1 pEC50 79.4 nM EC50 WO2018183145A1. Piperidinyl- and piperazinyl-substituted heteroaromatic carboxamides as modulators of gpr6 (2018)
ChEMBL Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay F 7.1 pEC50 79.43 nM EC50 WO-2018183145-A1. Piperidinyl- and piperazinyl-substituted heteroaromatic carboxamides as modulators of gpr6 (null)

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]