tolinapant [Ligand Id: 12704] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4173974 (Astx 660, Astx-660, Astx660, ASTX-660, ASTX660, Tolinapant)
  • baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490]
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  • X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490]
ChEMBL Inhibition of CIAP1 (unknown origin) B 7.92 pIC50 12 nM IC50 Eur J Med Chem (2019) 167: 76-95 [PMID:30769242]
ChEMBL Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrs B 9.66 pIC50 0.22 nM IC50 J Med Chem (2018) 61: 7314-7329 [PMID:30091600]
GtoPdb Measuring inhibition of intracellular degradation of cIAP1 in MDA-MB-231 cells - 9.66 pIC50 0.22 nM IC50 J Med Chem (2018) 61: 7314-7329 [PMID:30091600]
Genome polyprotein in Zika virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523954] [UniProtKB: A0A024AXB9]
ChEMBL Inhibition of Zika virus NS2B-NS3 protease B 6.1 pKi 800 nM Ki Bioorg Med Chem Lett (2020) 30: 126965-126965 [PMID:31980339]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG expressed in CHOK1 cells incubated for 600 secs at -80 mV holding potential by automated patch clamp assay B 4.16 pIC50 69000 nM IC50 J Med Chem (2018) 61: 7314-7329 [PMID:30091600]
X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170]
ChEMBL Inhibition of XIAP (unknown origin) B 7.4 pIC50 <40 nM IC50 Eur J Med Chem (2019) 167: 76-95 [PMID:30769242]
GtoPdb Determined in a cellular XIAP-caspase 9 immunoprecipitation assay - 8.55 pIC50 2.8 nM IC50 J Med Chem (2018) 61: 7314-7329 [PMID:30091600]
ChEMBL Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by immunoprecipitation assay B 8.55 pIC50 2.8 nM IC50 J Med Chem (2018) 61: 7314-7329 [PMID:30091600]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]