GDC-0339 [Ligand Id: 12708] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3648680 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] | ||||||||
| ChEMBL | Antagonist activity at alpha 1a adrenergic receptor (unknown origin) | B | 5.6 | pIC50 | 2500 | nM | IC50 | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
| ChEMBL | Inhibition of GSK3beta in human human MM1S cells | B | 4.64 | pIC50 | 23000 | nM | IC50 | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG expressed in HEK293 cells after 5 mins by patch clamp assay | B | 5.57 | pIC50 | 2700 | nM | IC50 | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
| mitogen-activated protein kinase kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6166] [GtoPdb: 2088] [UniProtKB: O95819] | ||||||||
| ChEMBL | Inhibition of MAP4K4 (unknown origin) by cell based assay | B | 5.24 | pIC50 | 5700 | nM | IC50 | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
| Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
| ChEMBL | Pim Kinase Binding Activity: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., and He, Q. Y. (2005) Expert Rev. Proteomics, 2:649-657). A fluorescent-labeled Pim-specific peptide substrate, was custom synthesized by American Peptide Company (Sunnyvale, Calif.). A fluorescent-labeled Pim-specific peptide substrate, was custom synthesized by American Peptide Company (Sunnyvale, Calif.). Reaction Buffer contained 10 mM HEPES, pH 7.2, 10 mM MgCl2, 0.01% Tween 20, 2 mM DTT. Termination Buffer contained 190 mM HEPES, pH 7.2, 0.015% Brij-35, 0.2% Coating Reagent 3 (Caliper Life Sciences, Hopkinton, Mass.), 20 mM EDTA. Separation Buffer contained 100 mM HEPES, pH 7.2, 0.015% Brij-35, 0.1% Coating Reagent 3, 1:200 Coating Reagent 8 (Caliper Life Sciences, Hopkinton, Mass.), 10 mM EDTA and 5% DMSO. | B | 10.4 | pKi | 0.04 | nM | Ki | US-8614206-B2. Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use (2013) |
| GtoPdb | - | - | 10.52 | pKi | 0.03 | nM | Ki | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
| ChEMBL | Inhibition of recombinant human PIM1 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay | B | 10.52 | pKi | 0.03 | nM | Ki | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
| Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9] | ||||||||
| GtoPdb | - | - | 10 | pKi | 0.1 | nM | Ki | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
| ChEMBL | Inhibition of recombinant human PIM2 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay | B | 10 | pKi | 0.1 | nM | Ki | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
| Pim-3 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5407] [GtoPdb: 2160] [UniProtKB: Q86V86] | ||||||||
| ChEMBL | Inhibition of recombinant human PIM3 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay | B | 10.7 | pKi | 0.02 | nM | Ki | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
| GtoPdb | - | - | 10.7 | pKi | 0.02 | nM | Ki | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Antagonist activity at 5HT1A receptor (unknown origin) | B | 5.31 | pIC50 | 4900 | nM | IC50 | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
| ChEMBL | Agonist activity at 5HT1A receptor (unknown origin) | B | 5.6 | pIC50 | 2500 | nM | IC50 | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
