cannabinor [Ligand Id: 12752] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3234035
  • CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
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  • CB2 receptor/Cannabinoid CB2 receptor in Human [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
  • CB2 receptor in Rat [GtoPdb: 57] [UniProtKB: Q9QZN9]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL Binding affinity to human CB1 receptor B 6.48 pKi 334 nM Ki J Med Chem (2013) 56: 8224-8256 [PMID:23865723]
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
GtoPdb - - 7.8 pKi 16 nM Ki Eur Urol (2010) 57: 1093-100 [PMID:20207474]
ChEMBL Binding affinity to human CB2 receptor B 8.05 pKi 9 nM Ki J Med Chem (2013) 56: 8224-8256 [PMID:23865723]
GtoPdb Determined in a GTPγS assay - 7.76 pEC50 17.4 nM EC50 Eur Urol (2010) 57: 1093-100 [PMID:20207474]
CB2 receptor in Rat [GtoPdb: 57] [UniProtKB: Q9QZN9]
GtoPdb - - 7.87 pKi 13.5 nM Ki Eur Urol (2010) 57: 1093-100 [PMID:20207474]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]