GNE-7883 [Ligand Id: 12814] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL5191316 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TEA domain transcription factor 1 in Human [GtoPdb: 3240] [UniProtKB: P28347] | ||||||||
| GtoPdb | Inhibition of TEAD1/TAZ binding | - | 7.3 | pIC50 | 50 | nM | IC50 | Nat Cancer (2023) 4: 812-828 [PMID:37277530] |
| GtoPdb | Inhibition of TEAD1/YAP binding | - | 7.4 | pIC50 | 40 | nM | IC50 | Nat Cancer (2023) 4: 812-828 [PMID:37277530] |
| TEA domain transcription factor 2 in Human [GtoPdb: 3241] [UniProtKB: Q15562] | ||||||||
| GtoPdb | TEAD2/YAP binding | - | 8 | pIC50 | 10 | nM | IC50 | Nat Cancer (2023) 4: 812-828 [PMID:37277530] |
| GtoPdb | TEAD2/TAZ binding | - | 8 | pIC50 | 10 | nM | IC50 | Nat Cancer (2023) 4: 812-828 [PMID:37277530] |
| TEA domain transcription factor 3 in Human [GtoPdb: 3242] [UniProtKB: Q99594] | ||||||||
| GtoPdb | Inhibition of TEAD3/TAZ binding | - | 7 | pIC50 | 100 | nM | IC50 | Nat Cancer (2023) 4: 812-828 [PMID:37277530] |
| GtoPdb | Inhibition of TEAD3/YAP binding | - | 7.05 | pIC50 | 90 | nM | IC50 | Nat Cancer (2023) 4: 812-828 [PMID:37277530] |
| TEA domain transcription factor 4 in Human [GtoPdb: 3243] [UniProtKB: Q15561] | ||||||||
| GtoPdb | Inhibition of TEAD4/TAZ binding | - | 7.52 | pIC50 | 30 | nM | IC50 | Nat Cancer (2023) 4: 812-828 [PMID:37277530] |
| GtoPdb | Inhibition of TEAD4/YAP binding | - | 7.52 | pIC50 | 30 | nM | IC50 | Nat Cancer (2023) 4: 812-828 [PMID:37277530] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
