ChEMBL ligand: CHEMBL399379
Acetyl-CoA carboxylase 1 in Human [ChEMBL: CHEMBL3351] [GtoPdb: 1263] [UniProtKB: Q13085] There should be some charts here, you may need to enable JavaScript!
Acetyl-CoA carboxylase 2 in Human [ChEMBL: CHEMBL4829] [GtoPdb: 1264] [UniProtKB: O00763] There should be some charts here, you may need to enable JavaScript!
ATP citrate lyase/ATP-citrate synthase in Human [ChEMBL: CHEMBL3720] [GtoPdb: 3245] [UniProtKB: P53396] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Acetyl-CoA carboxylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3351] [GtoPdb: 1263] [UniProtKB: Q13085]
ChEMBL	Inhibition of human ACC1	B	5.22	pIC50	6000	nM	IC50	Bioorg Med Chem Lett (2007) 17: 3208-3211 [PMID:17383874]
Acetyl-CoA carboxylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4829] [GtoPdb: 1264] [UniProtKB: O00763]
ChEMBL	Inhibition of human ACC2	B	4.92	pIC50	12000	nM	IC50	Bioorg Med Chem Lett (2007) 17: 3208-3211 [PMID:17383874]
ATP citrate lyase/ATP-citrate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3720] [GtoPdb: 3245] [UniProtKB: P53396]
ChEMBL	Inhibition of ATP citrate lyase (unknown origin) using sodium citrate as substrate after 60 mins by ADP-Glo luminescence assay	B	6.35	pIC50	442	nM	IC50	Eur J Med Chem (2017) 126: 920-928 [PMID:27997879]
ChEMBL	Inhibition of ATP citrate lyase (unknown origin) using sodium citrate as substrate by ADP-Glo luminescence assay	B	6.42	pIC50	377	nM	IC50	Bioorg Med Chem Lett (2017) 27: 929-935 [PMID:28129980]
ChEMBL	Inhibition of human recombinant ATP-citrate lyase	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2007) 17: 3208-3211 [PMID:17383874]
GtoPdb	-	-	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2007) 17: 3208-11 [PMID:17383874]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]