FHQC [Ligand Id: 12859] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4448591 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| FFA3 receptor/Free fatty acid receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5201] [GtoPdb: 227] [UniProtKB: O14843] | ||||||||
| GtoPdb | - | - | 5.65 | pEC50 | 2239 | nM | EC50 | Mol Pharmacol (2014) 86: 200-10 [PMID:24870406] |
| ChEMBL | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry | F | 5.65 | pEC50 | 2238.72 | nM | EC50 | J Med Chem (2020) 63: 3577-3595 [PMID:32141297] |
| ChEMBL | Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay | F | 6.27 | pEC50 | 537.03 | nM | EC50 | J Med Chem (2020) 63: 3577-3595 [PMID:32141297] |
| ChEMBL | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay | F | 6.28 | pEC50 | 524.81 | nM | EC50 | J Med Chem (2020) 63: 3577-3595 [PMID:32141297] |
| FFA3 receptor/Free fatty acid receptor 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3309101] [GtoPdb: 227] [UniProtKB: Q3UFD7] | ||||||||
| ChEMBL | Agonist activity at mouse FFA3 receptor | B | 5.42 | pEC50 | 3801.89 | nM | EC50 | J Med Chem (2020) 63: 3577-3595 [PMID:32141297] |
| FFA3 receptor/Free fatty acid receptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3886125] [GtoPdb: 227] [UniProtKB: B2GV46] | ||||||||
| ChEMBL | Agonist activity at rat FFA3 receptor | B | 5.87 | pEC50 | 1348.96 | nM | EC50 | J Med Chem (2020) 63: 3577-3595 [PMID:32141297] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
