TPT-004 [Ligand Id: 12993] activity data from GtoPdb

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  • L-Tryptophan hydroxylase 1 in Human [GtoPdb: 1241] [UniProtKB: P17752]
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  • L-Tryptophan hydroxylase 2 in Human [GtoPdb: 1242] [UniProtKB: Q8IWU9]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
L-Tryptophan hydroxylase 1 in Human [GtoPdb: 1241] [UniProtKB: P17752]
GtoPdb Binding affinity determined by SPR - 8.49 pKd 3.2 nM Kd J Med Chem (2023) :
GtoPdb - - 7.11 pIC50 77 nM IC50 J Med Chem (2023) :
L-Tryptophan hydroxylase 2 in Human [GtoPdb: 1242] [UniProtKB: Q8IWU9]
GtoPdb - - 7.8 pIC50 16 nM IC50 J Med Chem (2023) :

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.