ML216 [Ligand Id: 13026] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2426168
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  • BLM RecQ like helicase/Bloom syndrome protein in Human [ChEMBL: CHEMBL1293237] [GtoPdb: 3260] [UniProtKB: P54132]
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  • WRN RecQ like helicase/Werner syndrome ATP-dependent helicase in Human [ChEMBL: CHEMBL2146312] [GtoPdb: 3259] [UniProtKB: Q14191]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ATP-dependent DNA helicase Q1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293236] [UniProtKB: P46063]
ChEMBL Inhibition of RECQ1 (unknown origin) by gel-based DNA unwinding assay B 4.3 pIC50 >50000 nM IC50 Bioorg Med Chem Lett (2013) 23: 5660-5666 [PMID:24012121]
BLM RecQ like helicase/Bloom syndrome protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293237] [GtoPdb: 3260] [UniProtKB: P54132]
ChEMBL Inhibition of BLM helicase (unknown origin) assessed as branch migration activity B 4.3 pIC50 50000 nM IC50 Bioorg Med Chem Lett (2014) 24: 3006-3013 [PMID:24856061]
ChEMBL Inhibition of 5'-biotin labeled duplex forked-DNA binding to BLM (unknown origin) assessed as increase in unbound DNA levels after 1 hr by ELISA B 4.46 pIC50 34820 nM IC50 J Med Chem (2019) 62: 3147-3162 [PMID:30827110]
ChEMBL Inhibition of BLM helicase (unknown origin) binding to DNA B 5.52 pIC50 3000 nM IC50 Bioorg Med Chem Lett (2014) 24: 3006-3013 [PMID:24856061]
ChEMBL Inhibition of His-tagged BLM (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in BLM helicase unwinding activity using 5'-biotin labeled forked-DNA as substrate after 1 hr by PAGE analysis B 5.67 pIC50 2150 nM IC50 J Med Chem (2019) 62: 3147-3162 [PMID:30827110]
GtoPdb Inhibition of BLM-mediated DNA unwinding - 5.74 pIC50 1800 nM IC50 Bioorg Med Chem Lett (2013) 23: 5660-6 [PMID:24012121]
ChEMBL Inhibition of BLM (unknown origin) by gel-based DNA unwinding assay B 5.74 pIC50 1800 nM IC50 Bioorg Med Chem Lett (2013) 23: 5660-5666 [PMID:24012121]
WRN RecQ like helicase/Werner syndrome ATP-dependent helicase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2146312] [GtoPdb: 3259] [UniProtKB: Q14191]
ChEMBL Inhibition of WRN helicase (unknown origin) B 5.3 pIC50 5000 nM IC50 Bioorg Med Chem Lett (2014) 24: 3006-3013 [PMID:24856061]
ChEMBL Inhibition of WRN (unknown origin) by gel-based DNA unwinding assay B 5.57 pIC50 2700 nM IC50 Bioorg Med Chem Lett (2013) 23: 5660-5666 [PMID:24012121]
GtoPdb Inhibition of WRN-mediated DNA unwinding - 5.57 pIC50 2700 nM IC50 Bioorg Med Chem Lett (2013) 23: 5660-6 [PMID:24012121]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]