YHJ1039 [Ligand Id: 13032] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4846921 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400] | ||||||||
| ChEMBL | Inhibition of CK2alpha1 (unknown origin) | B | 7.86 | pIC50 | 13.9 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
| cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802] | ||||||||
| ChEMBL | Inhibition of CDK4 (unknown origin) | B | 8.07 | pIC50 | 8.5 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
| EPH receptor B1/Ephrin type-B receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762] | ||||||||
| ChEMBL | Inhibition of EphB1 (unknown origin) | B | 7.53 | pIC50 | 29.8 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
| discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345] | ||||||||
| ChEMBL | Inhibition of DDR1 (unknown origin) | B | 8.36 | pIC50 | 4.4 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
| protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] | ||||||||
| ChEMBL | Inhibition of FAK (unknown origin) | B | 8.01 | pIC50 | 9.7 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
| GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
| ChEMBL | Inhibition of recombinant FAK (unknown origin) by radiometric kinase assay | B | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG by patch-clamp assay | B | 5.57 | pIC50 | 2700 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
| c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922] | ||||||||
| ChEMBL | Inhibition of ROS (unknown origin) | B | 7.66 | pIC50 | 22 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
| FES proto-oncogene, tyrosine kinase/Tyrosine-protein kinase FES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5455] [GtoPdb: 2023] [UniProtKB: P07332] | ||||||||
| ChEMBL | Inhibition of Fes (unknown origin) | B | 8.31 | pIC50 | 4.9 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
| FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
| ChEMBL | Inhibition of Fyn (unknown origin) | B | 8.11 | pIC50 | 7.7 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
| Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458] | ||||||||
| ChEMBL | Inhibition of JAK1 (unknown origin) | B | 8.74 | pIC50 | 1.8 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
| Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
| ChEMBL | Inhibition of JAK3 (unknown origin) | B | 8.49 | pIC50 | 3.2 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
| LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
| ChEMBL | Inhibition of Lck (unknown origin) | B | 8.11 | pIC50 | 7.8 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
| ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949] | ||||||||
| ChEMBL | Inhibition of RET (unknown origin) | B | 8.54 | pIC50 | 2.9 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
| SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| ChEMBL | Inhibition of Src (unknown origin) | B | 8.47 | pIC50 | 3.4 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
| tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597] | ||||||||
| ChEMBL | Inhibition of TYK2 (unknown origin) | B | 8.37 | pIC50 | 4.3 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
