ChEMBL ligand: CHEMBL4785363 (Ccs 1477, Ccs1477, CCS-1477, CCS1477, Inobrodib)
CREB binding protein in Human [GtoPdb: 2734] [UniProtKB: Q92793] There should be some charts here, you may need to enable JavaScript!
E1A binding protein p300 in Human [GtoPdb: 2735] [UniProtKB: Q09472] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CREB binding protein in Human [GtoPdb: 2734] [UniProtKB: Q92793]
GtoPdb	Binding affinity for recombinant hCBP bromodomain determined by isothermal titration calorimetry (ITC).	-	7.85	pKd	14	nM	Kd	J Med Chem (2022) 65: 785-810 [PMID:34962793]
GtoPdb	Binding affinity for hCBP bromodomain determined by surface plasmon resonance (SPR).	-	8.77	pKd	1.7	nM	Kd	Cancer Discov (2021) 11: 1118-1137 [PMID:33431496]
E1A binding protein p300 in Human [GtoPdb: 2735] [UniProtKB: Q09472]
GtoPdb	Binding affinity for human p300 bromodomain determined by surface plasmon resonance (SPR)	-	8.77	pKd	1.7	nM	Kd	Cancer Discov (2021) 11: 1118-1137 [PMID:33431496]
GtoPdb	Inhibition of histone binding determined in a cell-based BRET assay.	-	7.72	pIC50	19	nM	IC50	Cancer Discov (2021) 11: 1118-1137 [PMID:33431496]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]