KU0058948 [Ligand Id: 13125] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL380648 (KU-0058948) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| poly(ADP-ribose) polymerase 1/Poly [ADP-ribose] polymerase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3105] [GtoPdb: 2771] [UniProtKB: P09874] | ||||||||
| GtoPdb | Binding affinity determined by isothermal titration calorimetry. | - | 7.72 | pKd | 19 | nM | Kd | J Med Chem (2009) 52: 3108-11 [PMID:19354255] |
| ChEMBL | Binding affinity to human PARP1 by isothermal titration colorimetry | B | 7.72 | pKd | 19 | nM | Kd | J Med Chem (2009) 52: 3108-3111 [PMID:19354255] |
| ChEMBL | Inhibitory activity against PARP1 | B | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1040-1044 [PMID:16290932] |
| ChEMBL | Inhibition of PARP1 by flashplate scintillation proximity assay | B | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2008) 51: 6581-6591 [PMID:18800822] |
| ChEMBL | Inhibition of human PARP1 | B | 8.47 | pIC50 | 3.4 | nM | IC50 | J Med Chem (2009) 52: 3108-3111 [PMID:19354255] |
| poly (ADP-ribose) polymerase 3/Poly [ADP-ribose] polymerase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5083] [GtoPdb: 2864] [UniProtKB: Q9Y6F1] | ||||||||
| GtoPdb | Binding affinity for PARP3 catalytic domain (178−532) determined by isothermal titration calorimetry. | - | 7.15 | pKd | 70 | nM | Kd | J Med Chem (2009) 52: 3108-11 [PMID:19354255] |
| ChEMBL | Binding affinity to human PARP3 PARP domain by isothermal titration colorimetry | B | 7.15 | pKd | 70 | nM | Kd | J Med Chem (2009) 52: 3108-3111 [PMID:19354255] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
