RX18 [Ligand Id: 13155] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3297829 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] | ||||||||
| ChEMBL | Displacement of [125I]BE2254 from human alpha1a receptor expressed in HEK293 cells | B | 9.03 | pKi | 0.93 | nM | Ki | Eur J Med Chem (2014) 83: 419-432 [PMID:24992070] |
| α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] | ||||||||
| ChEMBL | Displacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cells | B | 8.72 | pKi | 1.91 | nM | Ki | Eur J Med Chem (2014) 83: 419-432 [PMID:24992070] |
| α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] | ||||||||
| GtoPdb | - | - | 10.25 | pKi | - | - | - | Eur J Med Chem (2014) 83: 419-32 [PMID:24992070] |
| ChEMBL | Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells | B | 10.25 | pKi | 0.06 | nM | Ki | Eur J Med Chem (2014) 83: 419-432 [PMID:24992070] |
| α1D-adrenoceptor in Rat [GtoPdb: 24] [UniProtKB: P23944] | ||||||||
| GtoPdb | Antagonist potency determined in isolated rat thoracic aorta | - | 9.15 | pEC50 | - | - | - | Eur J Med Chem (2014) 83: 419-32 [PMID:24992070] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
