nefextinib [Ligand Id: 13213] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4297470 (Max-40279, MAX-40279) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| fms related receptor tyrosine kinase 3 in Human [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| GtoPdb | Inhibitor potency for FLT3-ITD fusion | - | 9.47 | pIC50 | 0.34 | nM | IC50 | CN106366093A. Fused pyrimidine compound, and intermediate, preparation method, composition and application of (2017) |
| GtoPdb | Inhibition potency for WT FLT3 | - | 9.55 | pIC50 | 0.28 | nM | IC50 | CN106366093A. Fused pyrimidine compound, and intermediate, preparation method, composition and application of (2017) |
| GtoPdb | Inhibitor potency for FLT3 D835Y mutant | - | 9.7 | pIC50 | 0.2 | nM | IC50 | CN106366093A. Fused pyrimidine compound, and intermediate, preparation method, composition and application of (2017) |
| LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
| GtoPdb | - | - | 8.26 | pIC50 | 5.5 | nM | IC50 | CN106366093A. Fused pyrimidine compound, and intermediate, preparation method, composition and application of (2017) |
| SRC proto-oncogene, non-receptor tyrosine kinase in Human [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| GtoPdb | - | - | 8.22 | pIC50 | 6 | nM | IC50 | CN106366093A. Fused pyrimidine compound, and intermediate, preparation method, composition and application of (2017) |
| YES proto-oncogene 1, Src family tyrosine kinase in Human [GtoPdb: 2284] [UniProtKB: P07947] | ||||||||
| GtoPdb | - | - | 8.24 | pIC50 | 5.8 | nM | IC50 | CN106366093A. Fused pyrimidine compound, and intermediate, preparation method, composition and application of (2017) |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
