K02288 [Ligand Id: 13266] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1230714 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| activin A receptor type 1/Activin receptor type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771] | ||||||||
| ChEMBL | Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P] | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2014) 57: 7900-7915 [PMID:25101911] |
| GtoPdb | - | - | 8.96 | pIC50 | 1.1 | nM | IC50 | Bioorg Med Chem Lett (2022) 55: 128452 [PMID:34780900] |
| transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897] | ||||||||
| ChEMBL | Inhibition of TGFbeta1-induced TGFbeta type 1 ALK5 in HEK293T cells after 30 mins by luciferase reporter gene assay | B | 5.47 | pIC50 | 3400 | nM | IC50 | J Med Chem (2014) 57: 7900-7915 [PMID:25101911] |
| ChEMBL | Inhibition of purified human ALK5 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P] | B | 6.55 | pIC50 | 280 | nM | IC50 | J Med Chem (2014) 57: 7900-7915 [PMID:25101911] |
| bone morphogenetic protein receptor type IA in Human [GtoPdb: 1786] [UniProtKB: P36894] | ||||||||
| GtoPdb | - | - | 7.46 | pIC50 | 34.3 | nM | IC50 | Bioorg Med Chem Lett (2022) 55: 128452 [PMID:34780900] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
