RY764 [Ligand Id: 1337] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL364346 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MC2 receptor/Melanocortin receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1965] [GtoPdb: 283] [UniProtKB: Q01718] | ||||||||
| ChEMBL | Inhibition concentration (binding affinity) against human melanocortin receptor 2 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| MC3 receptor/Melanocortin receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4644] [GtoPdb: 284] [UniProtKB: P41968] | ||||||||
| ChEMBL | Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells | B | 6.03 | pIC50 | 942 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| MC4 receptor/Melanocortin receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL259] [GtoPdb: 285] [UniProtKB: P32245] | ||||||||
| ChEMBL | Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells | B | 5.1 | pIC50 | 8000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| ChEMBL | Inhibition concentration (binding affinity) against dog melanocortin receptor 4 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells | B | 5.15 | pIC50 | 7000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| ChEMBL | Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells | B | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| GtoPdb | - | - | 8.1 | pIC50 | - | - | - | Bioorg Med Chem Lett (2005) 15: 3501-5 [PMID:15982875] |
| ChEMBL | Effective concentration (binding affinity) exhibited against human melanocortin receptor 4 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells) | F | 4.96 | pEC50 | 11000 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| ChEMBL | Concentration of compound at 50% maximum cAMP accumulation in human melanocortin receptor (hMC4R) | F | 4.96 | pEC50 | 11000 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| ChEMBL | Concentration of compound at 50% maximum cAMP accumulation in dog melanocortin receptor (dMC4R) | F | 4.96 | pEC50 | 11000 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| ChEMBL | Effective concentration (binding affinity) exhibited against human melanocortin receptor 4 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells) | F | 7.96 | pEC50 | 11 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| MC4 receptor/Melanocortin receptor 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3719] [GtoPdb: 285] [UniProtKB: P56450] | ||||||||
| ChEMBL | Inhibition concentration (binding affinity) against mouse melanocortin receptor 4 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells | B | 5.52 | pIC50 | 3000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| ChEMBL | Concentration of compound at 50% maximum cAMP accumulation in mouse melanocortin receptor (mMC4R) | F | 5.22 | pEC50 | 6000 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| MC4 receptor/Melanocortin receptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2700] [GtoPdb: 285] [UniProtKB: P70596] | ||||||||
| ChEMBL | Inhibition concentration (binding affinity) against rat melanocortin receptor 4 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells | B | 5.52 | pIC50 | 3000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| ChEMBL | Concentration of compound at 50% maximum cAMP accumulation in rat melanocortin receptor (rMC4R) | F | 5.3 | pEC50 | 5000 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| MC5 receptor/Melanocortin receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4608] [GtoPdb: 286] [UniProtKB: P33032] | ||||||||
| ChEMBL | Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells | B | 6.02 | pIC50 | 945 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
| ChEMBL | Effective concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells) | F | 6.07 | pEC50 | 850 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 3501-3505 [PMID:15982875] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
