3,3'-difluorobenzaldazine [Ligand Id: 1424] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL371811 (1,2-Bis(3-Fluorobenzylidene)Hydrazine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594] | ||||||||
| GtoPdb | - | - | 8.5 | pIC50 | - | - | - |
J Pharmacol Exp Ther (2004) 309: 568-77 [PMID:14747613]; Mol Pharmacol (2003) 64: 731-40 [PMID:12920211] |
| ChEMBL | Positive allosteric modulation of mGluR5 (unknown origin) | B | 5.59 | pEC50 | 2600 | nM | EC50 | J Med Chem (2013) 56: 7976-7996 [PMID:24050755] |
| ChEMBL | Effective concentration against metabotropic glutamate receptor 5 of human transfected into CHO cells | B | 8.63 | pEC50 | 2.36 | nM | EC50 | J Med Chem (2004) 47: 5825-5828 [PMID:15537338] |
| M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912] | ||||||||
| ChEMBL | Positive allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader | B | 5.59 | pEC50 | 2600 | nM | EC50 | J Med Chem (2014) 57: 7485-7498 [PMID:25180768] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
