L-703,606 [Ligand Id: 2104] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL24999 (L-703606) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| NK1 receptor/Neurokinin 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103] | ||||||||
| GtoPdb | - | - | 8.4 | pIC50 | - | - | - | J Biol Chem (1996) 271: 20250-7 [PMID:8702757] |
| ChEMBL | Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand | B | 8.8 | pIC50 | 1.6 | nM | IC50 | J Med Chem (2004) 47: 1315-1318 [PMID:14998319] |
| ChEMBL | Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cells | B | 7.61 | pEC50 | 24.4 | nM | EC50 | J Nat Prod (2006) 69: 432-435 [PMID:16562853] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
