flindokalner [Ligand Id: 2307] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL266510 (BMS-204352, BMS-204352-01, Flindokalner, Maxipost) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| KCa1.1/Calcium-activated potassium channel subunit alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4304] [GtoPdb: 380] [UniProtKB: Q12791] | ||||||||
| ChEMBL | Positive modulation of Kca 1.1 (unknown origin) | B | 6.45 | pEC50 | 352 | nM | EC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| GtoPdb | - | - | 6.5 | pEC50 | - | - | - | Nat Med (2001) 7: 471-7 [PMID:11283675] |
| Kv7.2/Voltage-gated potassium channel subunit Kv7.2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2476] [GtoPdb: 561] [UniProtKB: O43526] | ||||||||
| GtoPdb | - | - | 5 | pEC50 | - | - | - | Neuropharmacology (2001) 40: 888-98 [PMID:11378159] |
| ChEMBL | Positive modulatory activity at voltage-gated K channel 7.2 (unknown origin) | B | 5.62 | pEC50 | 2400 | nM | EC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Kv7.3/Voltage-gated potassium channel subunit Kv7.3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2684] [GtoPdb: 562] [UniProtKB: O43525] | ||||||||
| ChEMBL | Positive modulatory activity at voltage-gated K channel 7.3 (unknown origin) | B | 5.62 | pEC50 | 2400 | nM | EC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Kv7.4/Voltage-gated potassium channel subunit Kv7.4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3576] [GtoPdb: 563] [UniProtKB: P56696] | ||||||||
| GtoPdb | - | - | 5 | pEC50 | - | - | - | Am J Physiol, Cell Physiol (2001) 280: C859-66 [PMID:11245603] |
| ChEMBL | Positive modulatory activity at voltage-gated K channel 7.4 (unknown origin) | B | 5.62 | pEC50 | 2400 | nM | EC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Kv7.5/Voltage-gated potassium channel subunit Kv7.5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2925] [GtoPdb: 564] [UniProtKB: Q9NR82] | ||||||||
| GtoPdb | - | - | 5.6 | pEC50 | - | - | - | Eur J Pharmacol (2002) 437: 129-37 [PMID:11890900] |
| ChEMBL | Positive modulatory activity at voltage-gated K channel 7.5 (unknown origin) | B | 5.62 | pEC50 | 2400 | nM | EC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
