maxacalcitol [Ligand Id: 2784] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL333950 (1alpha,25-dihydroxy-22-oxavitamin d3, 22-oxacalcitriol, Maxacalcitol, OCT, Oxarol, Prezios, SCH 209579, SCH-209579) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Vitamin D receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1977] [GtoPdb: 605] [UniProtKB: P11473] | ||||||||
| ChEMBL | Activation of VDR in human HaCaT cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after 24 hrs by luciferase transcriptional reporter assay | B | 6.8 | pEC50 | 159.7 | nM | EC50 | J Med Chem (2016) 59: 5102-5108 [PMID:27070779] |
| ChEMBL | Activation of VDR in human Caco2 cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after 24 hrs by luciferase transcriptional reporter assay | B | 6.84 | pEC50 | 144.5 | nM | EC50 | J Med Chem (2016) 59: 5102-5108 [PMID:27070779] |
| ChEMBL | Transactivation of VDR in human Caco2 cells after 24 hrs by luciferase reporter gene assay | B | 7.39 | pEC50 | 40.8 | nM | EC50 | J Med Chem (2015) 58: 7881-7887 [PMID:26367019] |
| ChEMBL | Transactivation of VDR in human HaCaT cells after 24 hrs by luciferase reporter gene assay | B | 7.42 | pEC50 | 37.9 | nM | EC50 | J Med Chem (2015) 58: 7881-7887 [PMID:26367019] |
| ChEMBL | Activation of VDR in human Jurkat cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after 24 hrs by luciferase transcriptional reporter assay | B | 9.07 | pEC50 | 0.85 | nM | EC50 | J Med Chem (2016) 59: 5102-5108 [PMID:27070779] |
| Vitamin D receptor in Rat [GtoPdb: 605] [UniProtKB: P13053] | ||||||||
| GtoPdb | - | - | 8.21 | pEC50 | - | - | - | Bone (1993) 14: 47-51 [PMID:8443002] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
