ChEMBL ligand: CHEMBL412295
3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hamster [ChEMBL: CHEMBL1075267] [UniProtKB: P09610] There should be some charts here, you may need to enable JavaScript!
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hamster (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075267] [UniProtKB: P09610]
ChEMBL	Inhibition of Syrian hamster HMGR	B	4.65	pIC50	22300	nM	IC50	Bioorg Med Chem (2008) 16: 1309-1318 [PMID:17977732]
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035]
GtoPdb	Inhibition of HMG-CoA reductase	-	4.65	pIC50	22310	nM	IC50	Bioorg Med Chem (2010) 18: 4300-9 [PMID:20494585]
ChEMBL	Inhibition of HMG-CoA reductase by spectrophotometry	B	4.65	pIC50	22310	nM	IC50	Bioorg Med Chem (2010) 18: 4300-4309 [PMID:20494585]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]