SQ-34919 [Ligand Id: 3101] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL286760 (SQ-34919) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase in Bovine (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095178] [UniProtKB: P29702, P49355] | ||||||||
| ChEMBL | Inhibition of Farnesyltransferase from bovine brain | B | 4.1 | pIC50 | 80000 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 1291-1296 |
| squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] | ||||||||
| ChEMBL | Inhibition of squalene synthase from rat liver microsomes | B | 7.77 | pIC50 | 17 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 1291-1296 |
| GtoPdb | Inhibition rat liver microsomal squalene synthase | - | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1995) 38: 2596-605 [PMID:7629799] |
| GtoPdb | Inhibitory activity against rat liver microsomal squalene synthase was determined using [3H]-FPP as radioligand | - | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1996) 39: 657-60 [PMID:8576905] |
| ChEMBL | Inhibition rat liver microsomal squalene synthase | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1995) 38: 2596-2605 [PMID:7629799] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
