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ChEMBL ligand: CHEMBL319144 (Minodronate, Minodronic acid, NSC-725590, ONO-5920, YM 529, YM-529) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] | ||||||||
GtoPdb | Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting | - | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2010) 53: 3454-64 [PMID:20394422] |
ChEMBL | Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2010) 53: 3454-3464 [PMID:20394422] |
ChEMBL | Inhibition of FDPS (unknown origin) | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 126757-126757 [PMID:31699606] |
ChEMBL | Inhibition of human FPPS | B | 8.72 | pIC50 | 1.9 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 1117-1123 [PMID:25630225] |
Geranylgeranyl pyrophosphate synthase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075251] [UniProtKB: Q12051] | ||||||||
ChEMBL | Binding affinity to Saccharomyces cerevisiae GGPPS | B | 6.89 | pKi | 130 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895] |
ChEMBL | Inhibition of Saccharomyces cerevisiae GGPPS | B | 6.47 | pIC50 | 340 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895] |
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749] | ||||||||
ChEMBL | Binding affinity to human GGPPS | B | 5.74 | pKi | 1800 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895] |
GtoPdb | Inhibition of human recombinant geranylgeranyl diphosphate synthase | - | 4 | pIC50 | - | - | - | J Med Chem (2008) 51: 5594-607 [PMID:18800762] |
ChEMBL | Inhibition of human recombinant geranylgeranyl diphosphate synthase | B | 4 | pIC50 | 100000 | nM | IC50 | J Med Chem (2008) 51: 5594-5607 [PMID:18800762] |
ChEMBL | Inhibition of human GGPPS | B | 4.19 | pIC50 | 65000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895] |
GtoPdb | Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting | - | 6.17 | pIC50 | 670 | nM | IC50 | J Med Chem (2010) 53: 3454-64 [PMID:20394422] |
ChEMBL | Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting | B | 6.17 | pIC50 | 670 | nM | IC50 | J Med Chem (2010) 53: 3454-3464 [PMID:20394422] |
Geranyltranstransferase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075078] [UniProtKB: P22939] | ||||||||
ChEMBL | Inhibition of Escherichia coli FPPS | B | 5.96 | pIC50 | 1100 | nM | IC50 | J Med Chem (2006) 49: 7331-7341 [PMID:17149863] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]