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ChEMBL ligand: CHEMBL55140 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] | ||||||||
ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 | B | 7.92 | pKi | 12.1 | nM | Ki | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
GtoPdb | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | - | 7.92 | pKi | 12.1 | nM | Ki | J Med Chem (2008) 51: 2187-95 [PMID:18327899] |
ChEMBL | Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand | B | 7.96 | pKi | 11 | nM | Ki | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
GtoPdb | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | - | 8.96 | pKi | 1.09 | nM | Ki | J Med Chem (2008) 51: 2187-95 [PMID:18327899] |
ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | B | 8.96 | pKi | 1.09 | nM | Ki | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
ChEMBL | Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M) | B | 6.95 | pIC50 | 112.2 | nM | IC50 | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
ChEMBL | Inhibitory activity against farnesyl Pyrophosphate Synthase was determined | B | 6.96 | pIC50 | 110 | nM | IC50 | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
GtoPdb | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | - | 7.12 | pIC50 | 75.2 | nM | IC50 | J Med Chem (2008) 51: 2187-95 [PMID:18327899] |
ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 | B | 7.12 | pIC50 | 75.2 | nM | IC50 | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | B | 8.21 | pIC50 | 6.2 | nM | IC50 | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
GtoPdb | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | - | 8.21 | pIC50 | 6.2 | nM | IC50 | J Med Chem (2008) 51: 2187-95 [PMID:18327899] |
Farnesyl pyrophosphate synthase in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7] | ||||||||
ChEMBL | Inhibitory activity against FPPS in Leishmania major | B | 6.95 | pIC50 | 112.2 | nM | IC50 | J Med Chem (2006) 49: 215-223 [PMID:16392806] |
ChEMBL | Inhibitory activity against FPPS in Leishmania major | B | 6.95 | pIC50 | 112 | nM | IC50 | J Med Chem (2006) 49: 215-223 [PMID:16392806] |
Farnesyl pyrophosphate synthase in Leishmania major (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2150832] [UniProtKB: Q4QBL1] | ||||||||
ChEMBL | Inhibition of Leishmania major FPPS | B | 7.96 | pKi | 11 | nM | Ki | J Med Chem (2011) 54: 5955-5980 [PMID:21780776] |
Hexokinase in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4151] [UniProtKB: Q8ST54] | ||||||||
ChEMBL | Inhibitory activity against Trypanosoma cruzi hexokinase | B | 4.34 | pIC50 | 45740 | nM | IC50 | J Med Chem (2006) 49: 215-223 [PMID:16392806] |
ChEMBL | Inhibitory activity against Trypanosoma cruzi hexokinase | B | 4.34 | pIC50 | 45708.82 | nM | IC50 | J Med Chem (2006) 49: 215-223 [PMID:16392806] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]