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ChEMBL ligand: CHEMBL54004 (BPH-252) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] | ||||||||
ChEMBL | Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand | B | 6.64 | pKi | 230 | nM | Ki | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
ChEMBL | Inhibitory activity against farnesyl Pyrophosphate Synthase was determined | B | 5.62 | pIC50 | 2400 | nM | IC50 | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
ChEMBL | Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M) | B | 5.63 | pIC50 | 2344.23 | nM | IC50 | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
Farnesyl pyrophosphate synthase in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7] | ||||||||
ChEMBL | Inhibitory activity against Leishmania major Farnesyl diphosphate synthase | B | 5.63 | pIC50 | 2370 | nM | IC50 | J Med Chem (2004) 47: 175-187 [PMID:14695831] |
ChEMBL | Inhibitory activity against FPPS in Leishmania major | B | 5.63 | pIC50 | 2370 | nM | IC50 | J Med Chem (2006) 49: 215-223 [PMID:16392806] |
ChEMBL | Inhibitory activity against FPPS in Leishmania major | B | 5.63 | pIC50 | 2344.23 | nM | IC50 | J Med Chem (2006) 49: 215-223 [PMID:16392806] |
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749] | ||||||||
GtoPdb | Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase). | - | 6.14 | pIC50 | 720 | nM | IC50 | J Med Chem (2002) 45: 2185-96 [PMID:12014956] |
ChEMBL | Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase). | B | 6.14 | pIC50 | 720 | nM | IC50 | J Med Chem (2002) 45: 2185-2196 [PMID:12014956] |
ChEMBL | Inhibition of human recombinant geranylgeranyl diphosphate synthase | B | 6.15 | pIC50 | 710 | nM | IC50 | J Med Chem (2008) 51: 5594-5607 [PMID:18800762] |
GtoPdb | Inhibition of human recombinant geranylgeranyl diphosphate synthase | - | 6.15 | pIC50 | 710 | nM | IC50 | J Med Chem (2008) 51: 5594-607 [PMID:18800762] |
ChEMBL | Inhibition of human recombinant geranylgeranyl diphosphate synthase | B | 6.2 | pIC50 | 630.96 | nM | IC50 | J Med Chem (2008) 51: 5594-5607 [PMID:18800762] |
Hexokinase in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4151] [UniProtKB: Q8ST54] | ||||||||
ChEMBL | Inhibitory activity against Trypanosoma cruzi hexokinase | B | 5.56 | pIC50 | 2754.23 | nM | IC50 | J Med Chem (2006) 49: 215-223 [PMID:16392806] |
ChEMBL | Inhibitory activity against Trypanosoma cruzi hexokinase | B | 5.56 | pIC50 | 2750 | nM | IC50 | J Med Chem (2006) 49: 215-223 [PMID:16392806] |
ChEMBL | Inhibition of Trypanosoma cruzi hexokinase | B | 6.09 | pIC50 | 810 | nM | IC50 | J Biol Chem (2007) 282: 12377-12387 [PMID:17329254] |
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653] | ||||||||
ChEMBL | Inhibitory activity against Plasmodium berghei Ghana | F | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (2004) 47: 175-187 [PMID:14695831] |
ChEMBL | Inhibitory activity against Plasmodium berghei W2 | F | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2004) 47: 175-187 [PMID:14695831] |
ChEMBL | Inhibitory activity against Plasmodium berghei 3D7 | F | 6.08 | pIC50 | 830 | nM | IC50 | J Med Chem (2004) 47: 175-187 [PMID:14695831] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Growth inhibition of Plasmodium falciparum | F | 5.48 | pIC50 | 3300 | nM | IC50 | J Med Chem (2008) 51: 7827-7833 [PMID:19053772] |
ChEMBL | Growth inhibition of Plasmodium falciparum | F | 5.5 | pIC50 | 3162.28 | nM | IC50 | J Med Chem (2008) 51: 7827-7833 [PMID:19053772] |
ChEMBL | Antimicrobial activity against Plasmodium falciparum | F | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316] |
ChEMBL | In vitro growth inhibition against Plasmodium falciparum | F | 6.08 | pIC50 | 830 | nM | IC50 | J Med Chem (2004) 47: 175-187 [PMID:14695831] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]