GW848687X [Ligand Id: 3360] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL234940 (GW848687, GW848687X) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995] | ||||||||
| ChEMBL | Antagonist activity at human EP1 receptor | F | 9.1 | pKd | 0.79 | nM | Kd | Bioorg Med Chem Lett (2007) 17: 385-389 [PMID:17084082] |
| ChEMBL | Inhibition of human EP1 receptor | B | 8.6 | pIC50 | 2.51 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 385-389 [PMID:17084082] |
| ChEMBL | Displacement of [3H]PGE2 from EP1 receptor | B | 8.6 | pIC50 | 2.51 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1592-1597 [PMID:18262416] |
| ChEMBL | Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cells | B | 8.6 | pIC50 | 2.51 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2599-2603 [PMID:19332369] |
| GtoPdb | - | - | 8.6 | pIC50 | 2.5 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 385-9 [PMID:17084082] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
