VU-1545 [Ligand Id: 4059] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL210846 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu5 receptor in Human [GtoPdb: 293] [UniProtKB: P41594] | ||||||||
| GtoPdb | - | - | 8 | pEC50 | 9.6 | nM | EC50 | J Med Chem (2006) 49: 3332-44 [PMID:16722652] |
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
| ChEMBL | Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in HEK293 cells | B | 6.8 | pKi | 160 | nM | Ki | J Med Chem (2006) 49: 3332-3344 [PMID:16722652] |
| GtoPdb | - | - | 6.81 | pKi | 156 | nM | Ki | J Med Chem (2006) 49: 3332-44 [PMID:16722652] |
| ChEMBL | Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes | F | 8.02 | pEC50 | 9.6 | nM | EC50 | J Med Chem (2006) 49: 3332-3344 [PMID:16722652] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
