HC-056456 [Ligand Id: 4212] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL570345 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CatSper1/Cation channel sperm-associated protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628462] [GtoPdb: 388] [UniProtKB: Q8NEC5] | ||||||||
| ChEMBL | Inhibition of CatSper1 channel in human sperm assessed as decrease in sperm hyperactivity after 5 mins by computer-assisted sperm analysis | B | 4.4 | pIC50 | 40000 | nM | IC50 | US-20130123310-A1. Modulators of sperm hypermobility and uses thereof (2013) |
| GtoPdb | - | - | 4.7 | pIC50 | 20000 | nM | IC50 | PLoS ONE (2009) 4: e6844 [PMID:19718436] |
| Thioredoxin glutathione reductase in Schistosoma mansoni (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6110] [UniProtKB: Q962Y6] | ||||||||
| ChEMBL | Inhibition of Schistosoma mansoni TGR | B | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2009) 52: 6474-6483 [PMID:19761212] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
