RN1734 [Ligand Id: 4294] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2324347 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TRPV4/Transient receptor potential cation channel subfamily V member 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3119] [GtoPdb: 510] [UniProtKB: Q9HBA0] | ||||||||
| GtoPdb | - | - | 5.6 | pIC50 | 2300 | nM | IC50 | Biochem Biophys Res Commun (2009) 389: 490-4 [PMID:19737537] |
| ChEMBL | Inhibition of TRPV4 (unknown origin) | B | 5.64 | pIC50 | 2300 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| ChEMBL | Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced intracellular calcium after 10 mins in presence of 45Ca2+ by microbeta liquid scintillation counting method | B | 5.64 | pIC50 | 2300 | nM | IC50 | ACS Med Chem Lett (2017) 8: 549-554 [PMID:28523109] |
| ChEMBL | Antagonist activity at TRPV4 (unknown origin) | B | 5.64 | pIC50 | 2300 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127022-127022 [PMID:32063431] |
| ChEMBL | Antagonist activity at human TRPV4 | B | 5.64 | pIC50 | 2300 | nM | IC50 | Bioorg Med Chem (2020) 28: 115609-115609 [PMID:32690264] |
| TRPV4/Transient receptor potential cation channel subfamily V member 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6126] [GtoPdb: 510] [UniProtKB: Q9EPK8] | ||||||||
| GtoPdb | - | - | 5.2 | pIC50 | - | - | - | Biochem Biophys Res Commun (2009) 389: 490-4 [PMID:19737537] |
| ChEMBL | Antagonist activity at mouse TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced intracellular calcium after 10 mins in presence of 45Ca2+ by microbeta liquid scintillation counting method | B | 5.23 | pIC50 | 5900 | nM | IC50 | ACS Med Chem Lett (2017) 8: 549-554 [PMID:28523109] |
| ChEMBL | Antagonist activity at mouse TRPV4 | B | 5.23 | pIC50 | 5900 | nM | IC50 | Bioorg Med Chem (2020) 28: 115609-115609 [PMID:32690264] |
| TRPV4/Transient receptor potential cation channel subfamily V member 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2775] [GtoPdb: 510] [UniProtKB: Q9ERZ8] | ||||||||
| ChEMBL | Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced intracellular calcium after 10 mins in presence of 45Ca2+ by microbeta liquid scintillation counting method | B | 5.49 | pIC50 | 3200 | nM | IC50 | ACS Med Chem Lett (2017) 8: 549-554 [PMID:28523109] |
| ChEMBL | Antagonist activity at rat TRPV4 | B | 5.49 | pIC50 | 3200 | nM | IC50 | Bioorg Med Chem (2020) 28: 115609-115609 [PMID:32690264] |
| GtoPdb | - | - | 5.5 | pIC50 | - | - | - | Biochem Biophys Res Commun (2009) 389: 490-4 [PMID:19737537] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
