1-methyltryptophan [Ligand Id: 4694] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL513172 (1-Methyltryptophan) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902] | ||||||||
| ChEMBL | Inhibition of human recombinant indoleamine 2,3-dioxygenase | B | 4.21 | pKi | 62000 | nM | Ki | J Med Chem (2008) 51: 2634-2637 [PMID:18393489] |
| ChEMBL | Inhibition of IDO1 (unknown origin) | B | 4.42 | pKi | 38000 | nM | Ki | J Med Chem (2015) 58: 8762-8782 [PMID:26207924] |
| ChEMBL | Competitive inhibition of indoleamine-2,3-dioxygenase | B | 4.47 | pKi | 34000 | nM | Ki | Eur J Med Chem (2011) 46: 5680-5687 [PMID:21925773] |
| ChEMBL | Inhibition of human recombinant IDO using L-tryptophan as substrate | B | 4.47 | pKi | 34000 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 3403-3406 [PMID:24939758] |
| ChEMBL | Inhibition of human recombinant IDO assessed as inhibition of indoleamine 2,3-dioxygenase to kynurenine conversion after 60 mins by HPLC analysis | B | 4.52 | pKi | 30000 | nM | Ki | Bioorg Med Chem (2013) 21: 1159-1165 [PMID:23337802] |
| ChEMBL | Inhibition of IDO1 in human IFN-gamma stimulated human HeLa cells assessed as inhibition of kynurenine production using L-tryptophan substrate incubated for 24 hrs | B | 4.83 | pIC50 | 14690 | nM | IC50 | Eur J Med Chem (2017) 140: 293-304 [PMID:28963992] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
