sulfasalazine [Ligand Id: 4840] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL421 (Azulfidine, Azulfidine EN, Azulfidine en-tabs, Benzosulfa, Colizine, NSC-203730, NSC-667219, Salazopyrin, Salazopyrin e.c., Salazopyrin-en, Salazosulfapyridine, Salicylazosulfapyridine, S.a.s., S.a.s.-500, SAS-500, Sulfasalazine, Sulfasalazinum, Sulfasalazopyridine, Sulphasalazine, Ucine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| AICAR transformylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2518] [UniProtKB: P31939] | ||||||||
| ChEMBL | Inhibition of AICAR transformylase (unknown origin) | B | 4.66 | pKi | 22000 | nM | Ki | J Med Chem (2020) 63: 8314-8324 [PMID:32658475] |
| aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] | ||||||||
| ChEMBL | DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) | B | 4.77 | pIC50 | 17042 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] | ||||||||
| ChEMBL | DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) | B | 4.53 | pKi | 29301 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) | B | 4.36 | pIC50 | 43951 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973] | ||||||||
| ChEMBL | Inhibition of HA-tagged human NTCP expressed in human U2OS cells assessed as reduction in [14C]taurocholate uptake preincubated for 10 mins followed by [14C] taurocholate addition and further incubation for 10 mins by scintillation counting method | B | 5.02 | pIC50 | 9600 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 126623-126623 [PMID:31439379] |
| carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 1 esterase activity by noncompetitive Lineweaver-Burke plot | B | 5.16 | pKi | 6870 | nM | Ki | Bioorg Med Chem (2008) 16: 9101-9105 [PMID:18819808] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometry | B | 5.52 | pIC50 | 3040 | nM | IC50 | Bioorg Med Chem (2008) 16: 9101-9105 [PMID:18819808] |
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 2 esterase activity by non-competitive Lineweaver-Burke plot | B | 5.06 | pKi | 8720 | nM | Ki | Bioorg Med Chem (2008) 16: 9101-9105 [PMID:18819808] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 esterase activity by spectrophotometry | B | 5.35 | pIC50 | 4490 | nM | IC50 | Bioorg Med Chem (2008) 16: 9101-9105 [PMID:18819808] |
| Caspase 1/Caspase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466] | ||||||||
| ChEMBL | DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) | B | 4.54 | pIC50 | 28812 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Cystine/glutamate transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075149] [GtoPdb: 902] [UniProtKB: Q9UPY5] | ||||||||
| ChEMBL | Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid scintillation counting | B | 4.52 | pIC50 | 30000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 6184-6187 [PMID:21889337] |
| ChEMBL | Inhibition of xCT-mediated cystein/glutamate transporter (unknown origin) assessed as reduction in L-[14C]cyctein uptake | B | 6.8 | pIC50 | 160 | nM | IC50 | Eur J Med Chem (2019) 163: 215-242 [PMID:30522056] |
| Flavin reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5019] [UniProtKB: P30043] | ||||||||
| ChEMBL | Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetry | B | 6.36 | pKd | 440 | nM | Kd | J Med Chem (2022) 65: 2548-2557 [PMID:34957824] |
| ChEMBL | Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetry | B | 6.36 | pKd | 436.52 | nM | Kd | J Med Chem (2022) 65: 2548-2557 [PMID:34957824] |
| mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
| ChEMBL | DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) | B | 5.2 | pIC50 | 6332 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) | B | 4.63 | pIC50 | 23549 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
| ChEMBL | Activation of ABCB1 ATPase activity (unknown origin) expressed in baculovirus infected Sf9 insect cells using ATP as substrate measured after 1 hr by colorimetric assay | B | 6.04 | pEC50 | 916 | nM | EC50 | Eur J Med Chem (2020) 191: 112133-112133 [PMID:32105979] |
| Replicase polyprotein 1ab in Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295557] [UniProtKB: K9N7C7] | ||||||||
| ChEMBL | Binding affinity to MERS-CoV papain-like protease by SPR analysis | B | 5.12 | pKd | 7600 | nM | Kd | Bioorg Med Chem (2019) 27: 1981-1989 [PMID:30940566] |
| CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557] | ||||||||
| ChEMBL | DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) | B | 4.71 | pIC50 | 19639 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Proton-coupled folate transporter in Human [GtoPdb: 1213] [UniProtKB: Q96NT5] | ||||||||
| GtoPdb | - | - | 4.2 | pIC50 | 60000 | nM | IC50 | Cell (2006) 127: 917-28 [PMID:17129779] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
