miglitol [Ligand Id: 4842] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1561 (BAY M 1099, BAY-M-1099, Diastabol, Glyset, Miglitol, NSC-758702)
  • alpha glucosidase in Human [GtoPdb: 2611] [UniProtKB: P10253]
  • alpha glucosidase/Acidic alpha-glucosidase in Rat [ChEMBL: CHEMBL3513] [GtoPdb: 2611] [UniProtKB: Q6P7A9]
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  • Alpha-glucosidase in Aspergillus niger [ChEMBL: CHEMBL3435] [UniProtKB: P56526]
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  • glucosylceramidase beta/Beta-glucocerebrosidase in Human [ChEMBL: CHEMBL2179] [GtoPdb: 2978] [UniProtKB: P04062]
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  • Glycogen debranching enzyme in Rabbit [ChEMBL: CHEMBL5273] [UniProtKB: P35574]
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  • alpha glucosidase/Lysosomal alpha-glucosidase in Human [ChEMBL: CHEMBL2608] [GtoPdb: 2611] [UniProtKB: P10253]
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  • maltase-glucoamylase/Maltase-glucoamylase in Human [ChEMBL: CHEMBL2074] [GtoPdb: 2627] [UniProtKB: O43451]
  • maltase-glucoamylase in Mouse [GtoPdb: 2627]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
alpha glucosidase in Human [GtoPdb: 2611] [UniProtKB: P10253]
GtoPdb - - 6.46 pIC50 350 nM IC50 Bioorg Med Chem (2008) 16: 7330-6 [PMID:18595718]
alpha glucosidase/Acidic alpha-glucosidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3513] [GtoPdb: 2611] [UniProtKB: Q6P7A9]
ChEMBL Competitive inhibition of rat intestinal maltase by Lineweaver-Burk plot analysis B 6.34 pKi 460 nM Ki J Med Chem (2012) 55: 10347-10362 [PMID:23106358]
ChEMBL Inhibition of rat intestinal brush border membrane maltase B 5.89 pIC50 1300 nM IC50 Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718]
ChEMBL Inhibition of rat intestinal maltase using moltose as substrate B 5.89 pIC50 1300 nM IC50 J Med Chem (2012) 55: 10347-10362 [PMID:23106358]
ChEMBL Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry B 5.89 pIC50 1300 nM IC50 Bioorg Med Chem Lett (2014) 24: 3298-3301 [PMID:24973028]
ChEMBL Inhibition of Wistar rat small intestine maltase after 30 mins B 6.23 pIC50 590 nM IC50 Bioorg Med Chem Lett (2011) 21: 738-741 [PMID:21185187]
Alpha-glucosidase in Aspergillus niger (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3435] [UniProtKB: P56526]
ChEMBL Inhibition of Aspergillus niger alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 1 hr followed by substrate addition measured after 10 mins by spectrophotometric method B 4.24 pIC50 57140 nM IC50 Bioorg Med Chem Lett (2017) 27: 5291-5295 [PMID:29074258]
Alpha-mannosidase in Canavalia ensiformis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3392945] [UniProtKB: C0HJB3]
ChEMBL Inhibition of Canavalia ensiformis alpha-mannosidase using p-nitrophenyl-alpha-D-mannopyranoside as substrate preincubated for 1 hr followed by substrate addition measured after 10 mins by spectrophotometric method B 4.12 pIC50 75880 nM IC50 Bioorg Med Chem Lett (2017) 27: 5291-5295 [PMID:29074258]
Beta-galactosidase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3482] [UniProtKB: Q58D55]
ChEMBL Inhibition of bovine liver beta-galactosidase using 10 mM p-nitrophenyl-beta-D-galactopyranoside as substrate B 4 pKi 100000 nM Ki J Med Chem (2015) 58: 7820-7832 [PMID:26375725]
glucosylceramidase beta/Beta-glucocerebrosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2179] [GtoPdb: 2978] [UniProtKB: P04062]
ChEMBL Inhibition of human lysosomal beta-glucosidase B 4.08 pIC50 84000 nM IC50 Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718]
Glycogen debranching enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5273] [UniProtKB: P35574]
ChEMBL Inhibition of rabbit muscle amylo-1,6-glucosidase B 6.41 pIC50 390 nM IC50 Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718]
Lactase-phlorizin hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075131] [UniProtKB: P09848]
ChEMBL Inhibition of lactase by HPLC B 4.3 pIC50 50000 nM IC50 J Med Chem (2010) 53: 689-698 [PMID:20000679]
alpha glucosidase/Lysosomal alpha-glucosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2608] [GtoPdb: 2611] [UniProtKB: P10253]
ChEMBL Inhibition of lysosomal alpha-glucosidase by HPLC B 5.7 pIC50 2000 nM IC50 J Med Chem (2010) 53: 689-698 [PMID:20000679]
ChEMBL Inhibition of maltase in human Caco-2 cell model system after 2 hrs B 6 pIC50 1000 nM IC50 Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718]
ChEMBL Inhibition of human lysosomal alpha-glucosidase B 6.46 pIC50 350 nM IC50 Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718]
GtoPdb - - 6.46 pIC50 350 nM IC50 Bioorg Med Chem (2008) 16: 7330-6 [PMID:18595718]
maltase-glucoamylase/Maltase-glucoamylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2074] [GtoPdb: 2627] [UniProtKB: O43451]
GtoPdb Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay - 6 pKi 1000 nM Ki Bioorg Med Chem (2010) 18: 7794-8 [PMID:20970346]
ChEMBL Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay B 6 pKi 1000 nM Ki Bioorg Med Chem (2010) 18: 7794-7798 [PMID:20970346]
ChEMBL Inhibition of maltase by HPLC B 5.22 pIC50 6000 nM IC50 J Med Chem (2010) 53: 689-698 [PMID:20000679]
ChEMBL Inhibition of human small intestine microsomal maltase using maltose as substrate incubated for 30 mins by glucose-oxidase method B 5.43 pIC50 3700 nM IC50 Bioorg Med Chem (2016) 24: 3705-3715 [PMID:27325449]
ChEMBL Inhibition of human intestinal maltase using maltose as substrate incubated for 30 mins and immediately heated for 2 mins by glucose oxidase method B 5.43 pIC50 3700 nM IC50 Bioorg Med Chem Lett (2021) 33: 127751-127751 [PMID:33347966]
maltase-glucoamylase in Mouse [GtoPdb: 2627]
GtoPdb - - 6.68 pKi 211 nM Ki Bioorg Med Chem (2011) 19: 3929-34 [PMID:21669536]
Sucrase-isomaltase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2748] [UniProtKB: P14410]
ChEMBL Inhibition of sucrase by HPLC B 6.3 pIC50 500 nM IC50 J Med Chem (2010) 53: 689-698 [PMID:20000679]
Sucrase-isomaltase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3114] [UniProtKB: P23739]
ChEMBL Inhibition of rat intestinal isomaltase using isomaltase as substrate B 4.41 pIC50 39000 nM IC50 J Med Chem (2012) 55: 10347-10362 [PMID:23106358]
ChEMBL Inhibition of Wistar rat intestinal isomaltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry B 4.41 pIC50 39000 nM IC50 Bioorg Med Chem Lett (2014) 24: 3298-3301 [PMID:24973028]
ChEMBL Inhibition of Wistar rat small intestine isomaltase after 30 mins B 4.41 pIC50 39000 nM IC50 Bioorg Med Chem Lett (2011) 21: 738-741 [PMID:21185187]
ChEMBL Inhibition of rat small intestinal isomaltase using isomaltose as substrate incubated for 30 mins by glucose-oxidase method B 5.34 pIC50 4600 nM IC50 Bioorg Med Chem (2016) 24: 3705-3715 [PMID:27325449]
ChEMBL Inhibition of rat intestinal brush border membrane isomaltase B 5.92 pIC50 1200 nM IC50 Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718]
ChEMBL Inhibition of rat intestinal sucrase using sucrose as substrate B 6 pIC50 1000 nM IC50 J Med Chem (2012) 55: 10347-10362 [PMID:23106358]
ChEMBL Inhibition of Wistar rat small intestine sucrase after 30 mins B 6 pIC50 1000 nM IC50 Bioorg Med Chem Lett (2011) 21: 738-741 [PMID:21185187]
ChEMBL Inhibition of Wistar rat intestinal sucrase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry B 6 pIC50 1000 nM IC50 Bioorg Med Chem Lett (2014) 24: 3298-3301 [PMID:24973028]
ChEMBL Inhibition of rat small intestinal sucrase using sucrose as substrate incubated for 30 mins by glucose-oxidase method B 6.37 pIC50 430 nM IC50 Bioorg Med Chem (2016) 24: 3705-3715 [PMID:27325449]
ChEMBL Inhibition of rat intestinal brush border membrane sucrase B 6.96 pIC50 110 nM IC50 Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]