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ChEMBL ligand: CHEMBL363559 (dTTP) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547] | ||||||||
ChEMBL | Inhibition of DNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase M184V mutant assessed as incorporation of dTMP by burst assay using DNA/DNA Primer/Template combination | B | 4.14 | pKd | 73200 | nM | Kd | Antimicrob Agents Chemother (2008) 52: 2035-2042 [PMID:18391035] |
ChEMBL | Inhibition of RNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase assessed as incorporation of dTMP by burst assay using RNA/DNA Primer/Template combination | B | 4.17 | pKd | 67100 | nM | Kd | Antimicrob Agents Chemother (2008) 52: 2035-2042 [PMID:18391035] |
ChEMBL | Inhibition of DNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase assessed as incorporation of dTMP by burst assay using DNA/DNA Primer/Template combination | B | 4.81 | pKd | 15400 | nM | Kd | Antimicrob Agents Chemother (2008) 52: 2035-2042 [PMID:18391035] |
ChEMBL | Binding affinity to HIV1 LAI reverse transcriptase M184V mutant | B | 5.55 | pKd | 2850 | nM | Kd | Antimicrob Agents Chemother (2008) 52: 157-163 [PMID:17967907] |
ChEMBL | Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y/M184V mutant | B | 5.58 | pKd | 2650 | nM | Kd | Antimicrob Agents Chemother (2008) 52: 157-163 [PMID:17967907] |
ChEMBL | Binding affinity to HIV1 reverse transcriptase | B | 5.66 | pKd | 2200 | nM | Kd | Antimicrob Agents Chemother (2009) 53: 3715-3719 [PMID:19596885] |
ChEMBL | Binding affinity to wild type HIV1 LAI reverse transcriptase | B | 5.68 | pKd | 2080 | nM | Kd | Antimicrob Agents Chemother (2008) 52: 157-163 [PMID:17967907] |
ChEMBL | Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y mutant | B | 5.92 | pKd | 1200 | nM | Kd | Antimicrob Agents Chemother (2008) 52: 157-163 [PMID:17967907] |
ChEMBL | Inhibitory constant against HIV-1 reverse transcriptase | B | 7.21 | pKi | 61 | nM | Ki | J Med Chem (2005) 48: 2695-2700 [PMID:15801860] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]